Calsyntenin-3 regulates excitatory synapse formation via direct binding to neurexins
نویسندگان
چکیده
منابع مشابه
The Specific α-Neurexin Interactor Calsyntenin-3 Promotes Excitatory and Inhibitory Synapse Development
Perturbations of cell surface synapse-organizing proteins, particularly α-neurexins, contribute to neurodevelopmental and psychiatric disorders. From an unbiased screen, we identify calsyntenin-3 (alcadein-β) as a synapse-organizing protein unique in binding and recruiting α-neurexins, but not β-neurexins. Calsyntenin-3 is present in many pyramidal neurons throughout cortex and hippocampus but ...
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CNR Institute of Neuroscience and Department of Pharmacology, University of Milan, 20129 Milan, Italy, Dulbecco Telethon Institute, Rome, Italy, Department of Human Physiology, University of Milan, 20133 Milan, Italy, Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, 134 Shinchon-dong, Seodaemun-gu, Seoul 120-749, South Korea and Neuromuscular Diseases an...
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ژورنال
عنوان ژورنال: IBRO Reports
سال: 2019
ISSN: 2451-8301
DOI: 10.1016/j.ibror.2019.07.1646